“EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF AVERRHOA BILIMBI USING VARIOUS ANIMAL MODELS”

Aim of the study: Averrhoa bilimbi is used to treat a variety illnesses, including those that affect central nervous system. In this study, albino rats were given methanolic extract leaves (MEAB) investigate its effects using behavioral assays are sensitive antidepressants with clinical efficacy. Methodology: When mice subjected Tail suspension test (TST) and Forced swim (FST), (125,250, 500mg/kg) was able reduce immobility duration dose-dependently; comparable standard medicines, i.e., imipramine (10mg/kg). Results: Our research revealed MEAB, when administered at greater concentrations, significantly (p<0.0001) reduced in tail forced model depression Imipramine. These findings showed AB exhibited vivo selectively antidepressant. Conclusion: The results summary, extracts may have antidepressant properties make them potentially useful for treating patients depressive disorders. However, more required comprehend mechanism action pinpoint key ingredient produces antidepressant-like activity.